To setup a SQLite data source using libiodbc do the following steps: 1. Add the driver to /etc/odbcinst.ini: [ODBC Drivers] SQLite3=Installed [SQLite3] Description=SQLite3 ODBC Driver Driver=/usr/lib/libsqlite3odbc.so Setup=/usr/lib/libsqlite3odbc.so Threading=2 2. Add a DSN to your private ~/.odbc.ini or the system /etc/odbc.ini file: [ODBC Data Sources] mysqlitedb=SQLite3 [mysqlitedb] Driver=/usr/lib/libsqliteodbc.so Description=My SQLite test database Database=/home/johndoe/databases/mytest.db # optional lock timeout in milliseconds Timeout=2000 Alternatively, to setup a SQLite data source using unixODBC: 1. Add the driver to /etc/odbcinst.ini: [SQLite3] Description=SQLite3 ODBC Driver Driver=/usr/lib/libsqlite3odbc.so Setup=/usr/lib/libsqlite3odbc.so Threading=2 2. Add a DSN to your private ~/.odbc.ini or the system /etc/odbc.ini file: [mysqlitedb] Description=My SQLite test database Driver=SQLite3 Database=/home/johndoe/databases/mytest.db # optional lock timeout in milliseconds Timeout=2000