The Linux Wacom Project manages the drivers, libraries, and documentation
for configuring and running Wacom tablets under the Linux operating system.
It contains diagnostic applications as well as updated kernel drivers and
XFree86/Xorg XInput drivers.

One way of loading the kernel module at boot, add edit /etc/rc.d/rc.modules
adding a line similar to the following:
	/sbin/modprobe wacom

Please see the following url for X server configuration:
http://linuxwacom.sourceforge.net/index.php/howto/inputdev
See also the wacom(4) manpage